PhytophthoraEffectorV1, Main, Exploration, bibRecord, 000051

Phytophthora sojae Effector PsAvh240 Inhibits Host Aspartic Protease Secretion to Promote Infection.

Identifieur interne : 000051 ( Main/Exploration ); précédent : 000050; suivant : 000052

Phytophthora sojae Effector PsAvh240 Inhibits Host Aspartic Protease Secretion to Promote Infection.

Source :

Molecular plant [ 1752-9867 ] ; 2019.

RBID : pubmed:30703565

Descripteurs français

KwdFr :
- Aspartic acid proteases (métabolisme), Facteurs de virulence (), Facteurs de virulence (métabolisme), Immunité des plantes (MeSH), Interactions hôte-pathogène (MeSH), Maladies des plantes (immunologie), Maladies des plantes (microbiologie), Membrane cellulaire (métabolisme), Modèles moléculaires (MeSH), Multimérisation de protéines (MeSH), Phytophthora (métabolisme), Phytophthora (physiologie), Soja (cytologie), Soja (enzymologie), Soja (immunologie), Soja (microbiologie), Structure quaternaire des protéines (MeSH), Séquence d'acides aminés (MeSH), Transport de protéines (MeSH).
MESH :
- cytologie : Soja.
- enzymologie : Soja.
- immunologie : Maladies des plantes, Soja.
- microbiologie : Maladies des plantes, Soja.
- métabolisme : Aspartic acid proteases, Facteurs de virulence, Membrane cellulaire, Phytophthora.
- physiologie : Phytophthora.
- Facteurs de virulence, Immunité des plantes, Interactions hôte-pathogène, Modèles moléculaires, Multimérisation de protéines, Structure quaternaire des protéines, Séquence d'acides aminés, Transport de protéines.

English descriptors

KwdEn :
- Amino Acid Sequence (MeSH), Aspartic Acid Proteases (metabolism), Cell Membrane (metabolism), Host-Pathogen Interactions (MeSH), Models, Molecular (MeSH), Phytophthora (metabolism), Phytophthora (physiology), Plant Diseases (immunology), Plant Diseases (microbiology), Plant Immunity (MeSH), Protein Multimerization (MeSH), Protein Structure, Quaternary (MeSH), Protein Transport (MeSH), Soybeans (cytology), Soybeans (enzymology), Soybeans (immunology), Soybeans (microbiology), Virulence Factors (chemistry), Virulence Factors (metabolism).
MESH :
- chemical , chemistry : Virulence Factors.
- chemical , metabolism : Aspartic Acid Proteases, Virulence Factors.
- cytology : Soybeans.
- enzymology : Soybeans.
- immunology : Plant Diseases, Soybeans.
- metabolism : Cell Membrane, Phytophthora.
- microbiology : Plant Diseases, Soybeans.
- physiology : Phytophthora.
- Amino Acid Sequence, Host-Pathogen Interactions, Models, Molecular, Plant Immunity, Protein Multimerization, Protein Structure, Quaternary, Protein Transport.

Abstract

Plants secrete defense molecules into the extracellular space (the apoplast) to combat attacking microbes. However, the mechanisms by which successful pathogens subvert plant apoplastic immunity remain poorly understood. In this study, we show that PsAvh240, a membrane-localized effector of the soybean pathogen Phytophthora sojae, promotes P. sojae infection in soybean hairy roots. We found that PsAvh240 interacts with the soybean-resistant aspartic protease GmAP1 in planta and suppresses the secretion of GmAP1 into the apoplast. By solving its crystal structure we revealed that PsAvh240 contain six α helices and two WY motifs. The first two α helices of PsAvh240 are responsible for its plasma membrane-localization and are required for PsAvh240's interaction with GmAP1. The second WY motifs of two PsAvh240 molecules form a handshake arrangement resulting in a handshake-like dimer. This dimerization is required for the effector's repression of GmAP1 secretion. Taken together, these data reveal that PsAvh240 localizes at the plasma membrane to interfere with GmAP1 secretion, which represents an effective mechanism by which effector proteins suppress plant apoplastic immunity.

DOI: 10.1016/j.molp.2019.01.017
PubMed: 30703565

Affiliations:

République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000059
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Le document en format XML

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<author><name sortKey="Yang, Bo" sort="Yang, Bo" uniqKey="Yang B" first="Bo" last="Yang">Bo Yang</name>
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<author><name sortKey="Jing, Maofeng" sort="Jing, Maofeng" uniqKey="Jing M" first="Maofeng" last="Jing">Maofeng Jing</name>
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<author><name sortKey="Li, Haiyang" sort="Li, Haiyang" uniqKey="Li H" first="Haiyang" last="Li">Haiyang Li</name>
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<author><name sortKey="Xia, Yeqiang" sort="Xia, Yeqiang" uniqKey="Xia Y" first="Yeqiang" last="Xia">Yeqiang Xia</name>
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<author><name sortKey="Xu, Yuanpeng" sort="Xu, Yuanpeng" uniqKey="Xu Y" first="Yuanpeng" last="Xu">Yuanpeng Xu</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201204</wicri:regionArea>
<wicri:noRegion>Shanghai 201204</wicri:noRegion>
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<author><name sortKey="Yu, Feng" sort="Yu, Feng" uniqKey="Yu F" first="Feng" last="Yu">Feng Yu</name>
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<author><name sortKey="Wang, Yan" sort="Wang, Yan" uniqKey="Wang Y" first="Yan" last="Wang">Yan Wang</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Ye, Wenwu" sort="Ye, Wenwu" uniqKey="Ye W" first="Wenwu" last="Ye">Wenwu Ye</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Dong, Suomeng" sort="Dong, Suomeng" uniqKey="Dong S" first="Suomeng" last="Dong">Suomeng Dong</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095</wicri:regionArea>
<wicri:noRegion>Nanjing 210095</wicri:noRegion>
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<author><name sortKey="Xing, Weiman" sort="Xing, Weiman" uniqKey="Xing W" first="Weiman" last="Xing">Weiman Xing</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Wang, Yuanchao" sort="Wang, Yuanchao" uniqKey="Wang Y" first="Yuanchao" last="Wang">Yuanchao Wang</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Phytophthora sojae Effector PsAvh240 Inhibits Host Aspartic Protease Secretion to Promote Infection.</title>
<author><name sortKey="Guo, Baodian" sort="Guo, Baodian" uniqKey="Guo B" first="Baodian" last="Guo">Baodian Guo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095</wicri:regionArea>
<wicri:noRegion>Nanjing 210095</wicri:noRegion>
</affiliation>
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<author><name sortKey="Wang, Haonan" sort="Wang, Haonan" uniqKey="Wang H" first="Haonan" last="Wang">Haonan Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095</wicri:regionArea>
<wicri:noRegion>Nanjing 210095</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Bo" sort="Yang, Bo" uniqKey="Yang B" first="Bo" last="Yang">Bo Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095</wicri:regionArea>
<wicri:noRegion>Nanjing 210095</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jiang, Wenjing" sort="Jiang, Wenjing" uniqKey="Jiang W" first="Wenjing" last="Jiang">Wenjing Jiang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095</wicri:regionArea>
<wicri:noRegion>Nanjing 210095</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jing, Maofeng" sort="Jing, Maofeng" uniqKey="Jing M" first="Maofeng" last="Jing">Maofeng Jing</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095</wicri:regionArea>
<wicri:noRegion>Nanjing 210095</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Haiyang" sort="Li, Haiyang" uniqKey="Li H" first="Haiyang" last="Li">Haiyang Li</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095</wicri:regionArea>
<wicri:noRegion>Nanjing 210095</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xia, Yeqiang" sort="Xia, Yeqiang" uniqKey="Xia Y" first="Yeqiang" last="Xia">Yeqiang Xia</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095</wicri:regionArea>
<wicri:noRegion>Nanjing 210095</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Yuanpeng" sort="Xu, Yuanpeng" uniqKey="Xu Y" first="Yuanpeng" last="Xu">Yuanpeng Xu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095</wicri:regionArea>
<wicri:noRegion>Nanjing 210095</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hu, Qinli" sort="Hu, Qinli" uniqKey="Hu Q" first="Qinli" last="Hu">Qinli Hu</name>
<affiliation wicri:level="1"><nlm:affiliation>National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201204, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201204</wicri:regionArea>
<wicri:noRegion>Shanghai 201204</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Fangfang" sort="Wang, Fangfang" uniqKey="Wang F" first="Fangfang" last="Wang">Fangfang Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201204, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201204</wicri:regionArea>
<wicri:noRegion>Shanghai 201204</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yu, Feng" sort="Yu, Feng" uniqKey="Yu F" first="Feng" last="Yu">Feng Yu</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Applied Physics, Chinese Academy of Sciences, No. 239 Zhangheng Road, Shanghai 201204, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Institute of Applied Physics, Chinese Academy of Sciences, No. 239 Zhangheng Road, Shanghai 201204</wicri:regionArea>
<wicri:noRegion>Shanghai 201204</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Yan" sort="Wang, Yan" uniqKey="Wang Y" first="Yan" last="Wang">Yan Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095</wicri:regionArea>
<wicri:noRegion>Nanjing 210095</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ye, Wenwu" sort="Ye, Wenwu" uniqKey="Ye W" first="Wenwu" last="Ye">Wenwu Ye</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095</wicri:regionArea>
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<author><name sortKey="Dong, Suomeng" sort="Dong, Suomeng" uniqKey="Dong S" first="Suomeng" last="Dong">Suomeng Dong</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Xing, Weiman" sort="Xing, Weiman" uniqKey="Xing W" first="Weiman" last="Xing">Weiman Xing</name>
<affiliation wicri:level="1"><nlm:affiliation>National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201204, China. Electronic address: wmxing@sibs.ac.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201204</wicri:regionArea>
<wicri:noRegion>Shanghai 201204</wicri:noRegion>
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</author>
<author><name sortKey="Wang, Yuanchao" sort="Wang, Yuanchao" uniqKey="Wang Y" first="Yuanchao" last="Wang">Yuanchao Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China. Electronic address: wangyc@njau.edu.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095</wicri:regionArea>
<wicri:noRegion>Nanjing 210095</wicri:noRegion>
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<series><title level="j">Molecular plant</title>
<idno type="eISSN">1752-9867</idno>
<imprint><date when="2019" type="published">2019</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term>
<term>Aspartic Acid Proteases (metabolism)</term>
<term>Cell Membrane (metabolism)</term>
<term>Host-Pathogen Interactions (MeSH)</term>
<term>Models, Molecular (MeSH)</term>
<term>Phytophthora (metabolism)</term>
<term>Phytophthora (physiology)</term>
<term>Plant Diseases (immunology)</term>
<term>Plant Diseases (microbiology)</term>
<term>Plant Immunity (MeSH)</term>
<term>Protein Multimerization (MeSH)</term>
<term>Protein Structure, Quaternary (MeSH)</term>
<term>Protein Transport (MeSH)</term>
<term>Soybeans (cytology)</term>
<term>Soybeans (enzymology)</term>
<term>Soybeans (immunology)</term>
<term>Soybeans (microbiology)</term>
<term>Virulence Factors (chemistry)</term>
<term>Virulence Factors (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Aspartic acid proteases (métabolisme)</term>
<term>Facteurs de virulence ()</term>
<term>Facteurs de virulence (métabolisme)</term>
<term>Immunité des plantes (MeSH)</term>
<term>Interactions hôte-pathogène (MeSH)</term>
<term>Maladies des plantes (immunologie)</term>
<term>Maladies des plantes (microbiologie)</term>
<term>Membrane cellulaire (métabolisme)</term>
<term>Modèles moléculaires (MeSH)</term>
<term>Multimérisation de protéines (MeSH)</term>
<term>Phytophthora (métabolisme)</term>
<term>Phytophthora (physiologie)</term>
<term>Soja (cytologie)</term>
<term>Soja (enzymologie)</term>
<term>Soja (immunologie)</term>
<term>Soja (microbiologie)</term>
<term>Structure quaternaire des protéines (MeSH)</term>
<term>Séquence d'acides aminés (MeSH)</term>
<term>Transport de protéines (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Virulence Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Aspartic Acid Proteases</term>
<term>Virulence Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Soja</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Soybeans</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Soja</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Soybeans</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Maladies des plantes</term>
<term>Soja</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Plant Diseases</term>
<term>Soybeans</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Membrane</term>
<term>Phytophthora</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Maladies des plantes</term>
<term>Soja</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Plant Diseases</term>
<term>Soybeans</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Aspartic acid proteases</term>
<term>Facteurs de virulence</term>
<term>Membrane cellulaire</term>
<term>Phytophthora</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Phytophthora</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Phytophthora</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Host-Pathogen Interactions</term>
<term>Models, Molecular</term>
<term>Plant Immunity</term>
<term>Protein Multimerization</term>
<term>Protein Structure, Quaternary</term>
<term>Protein Transport</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Facteurs de virulence</term>
<term>Immunité des plantes</term>
<term>Interactions hôte-pathogène</term>
<term>Modèles moléculaires</term>
<term>Multimérisation de protéines</term>
<term>Structure quaternaire des protéines</term>
<term>Séquence d'acides aminés</term>
<term>Transport de protéines</term>
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<front><div type="abstract" xml:lang="en">Plants secrete defense molecules into the extracellular space (the apoplast) to combat attacking microbes. However, the mechanisms by which successful pathogens subvert plant apoplastic immunity remain poorly understood. In this study, we show that PsAvh240, a membrane-localized effector of the soybean pathogen Phytophthora sojae, promotes P. sojae infection in soybean hairy roots. We found that PsAvh240 interacts with the soybean-resistant aspartic protease GmAP1 in planta and suppresses the secretion of GmAP1 into the apoplast. By solving its crystal structure we revealed that PsAvh240 contain six α helices and two WY motifs. The first two α helices of PsAvh240 are responsible for its plasma membrane-localization and are required for PsAvh240's interaction with GmAP1. The second WY motifs of two PsAvh240 molecules form a handshake arrangement resulting in a handshake-like dimer. This dimerization is required for the effector's repression of GmAP1 secretion. Taken together, these data reveal that PsAvh240 localizes at the plasma membrane to interfere with GmAP1 secretion, which represents an effective mechanism by which effector proteins suppress plant apoplastic immunity.</div>
</front>
</TEI>
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<DateCompleted><Year>2019</Year>
<Month>11</Month>
<Day>22</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>11</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1752-9867</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>12</Volume>
<Issue>4</Issue>
<PubDate><Year>2019</Year>
<Month>04</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Molecular plant</Title>
<ISOAbbreviation>Mol Plant</ISOAbbreviation>
</Journal>
<ArticleTitle>Phytophthora sojae Effector PsAvh240 Inhibits Host Aspartic Protease Secretion to Promote Infection.</ArticleTitle>
<Pagination><MedlinePgn>552-564</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S1674-2052(19)30023-1</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.molp.2019.01.017</ELocationID>
<Abstract><AbstractText>Plants secrete defense molecules into the extracellular space (the apoplast) to combat attacking microbes. However, the mechanisms by which successful pathogens subvert plant apoplastic immunity remain poorly understood. In this study, we show that PsAvh240, a membrane-localized effector of the soybean pathogen Phytophthora sojae, promotes P. sojae infection in soybean hairy roots. We found that PsAvh240 interacts with the soybean-resistant aspartic protease GmAP1 in planta and suppresses the secretion of GmAP1 into the apoplast. By solving its crystal structure we revealed that PsAvh240 contain six α helices and two WY motifs. The first two α helices of PsAvh240 are responsible for its plasma membrane-localization and are required for PsAvh240's interaction with GmAP1. The second WY motifs of two PsAvh240 molecules form a handshake arrangement resulting in a handshake-like dimer. This dimerization is required for the effector's repression of GmAP1 secretion. Taken together, these data reveal that PsAvh240 localizes at the plasma membrane to interfere with GmAP1 secretion, which represents an effective mechanism by which effector proteins suppress plant apoplastic immunity.</AbstractText>
<CopyrightInformation>Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Baodian</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Haonan</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Bo</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jiang</LastName>
<ForeName>Wenjing</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jing</LastName>
<ForeName>Maofeng</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Haiyang</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xia</LastName>
<ForeName>Yeqiang</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Yuanpeng</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hu</LastName>
<ForeName>Qinli</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201204, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Fangfang</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201204, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Feng</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Shanghai Institute of Applied Physics, Chinese Academy of Sciences, No. 239 Zhangheng Road, Shanghai 201204, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Yan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ye</LastName>
<ForeName>Wenwu</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dong</LastName>
<ForeName>Suomeng</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xing</LastName>
<ForeName>Weiman</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201204, China. Electronic address: wmxing@sibs.ac.cn.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Yuanchao</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing 210095, China. Electronic address: wangyc@njau.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>01</Month>
<Day>28</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Mol Plant</MedlineTA>
<NlmUniqueID>101465514</NlmUniqueID>
<ISSNLinking>1674-2052</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D037521">Virulence Factors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.-</RegistryNumber>
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<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
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<MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057865" MajorTopicYN="N">Plant Immunity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055503" MajorTopicYN="N">Protein Multimerization</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020836" MajorTopicYN="N">Protein Structure, Quaternary</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D021381" MajorTopicYN="N">Protein Transport</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013025" MajorTopicYN="N">Soybeans</DescriptorName>
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<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
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<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
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<Keyword MajorTopicYN="Y">effector triggered susceptibility</Keyword>
<Keyword MajorTopicYN="Y">handshake-like dimer</Keyword>
<Keyword MajorTopicYN="Y">plant apoplastic immunity</Keyword>
<Keyword MajorTopicYN="Y">soybean aspartic protease</Keyword>
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<Month>10</Month>
<Day>10</Day>
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<Month>12</Month>
<Day>20</Day>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Guo, Baodian" sort="Guo, Baodian" uniqKey="Guo B" first="Baodian" last="Guo">Baodian Guo</name>
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<name sortKey="Dong, Suomeng" sort="Dong, Suomeng" uniqKey="Dong S" first="Suomeng" last="Dong">Suomeng Dong</name>
<name sortKey="Hu, Qinli" sort="Hu, Qinli" uniqKey="Hu Q" first="Qinli" last="Hu">Qinli Hu</name>
<name sortKey="Jiang, Wenjing" sort="Jiang, Wenjing" uniqKey="Jiang W" first="Wenjing" last="Jiang">Wenjing Jiang</name>
<name sortKey="Jing, Maofeng" sort="Jing, Maofeng" uniqKey="Jing M" first="Maofeng" last="Jing">Maofeng Jing</name>
<name sortKey="Li, Haiyang" sort="Li, Haiyang" uniqKey="Li H" first="Haiyang" last="Li">Haiyang Li</name>
<name sortKey="Wang, Fangfang" sort="Wang, Fangfang" uniqKey="Wang F" first="Fangfang" last="Wang">Fangfang Wang</name>
<name sortKey="Wang, Haonan" sort="Wang, Haonan" uniqKey="Wang H" first="Haonan" last="Wang">Haonan Wang</name>
<name sortKey="Wang, Yan" sort="Wang, Yan" uniqKey="Wang Y" first="Yan" last="Wang">Yan Wang</name>
<name sortKey="Wang, Yuanchao" sort="Wang, Yuanchao" uniqKey="Wang Y" first="Yuanchao" last="Wang">Yuanchao Wang</name>
<name sortKey="Xia, Yeqiang" sort="Xia, Yeqiang" uniqKey="Xia Y" first="Yeqiang" last="Xia">Yeqiang Xia</name>
<name sortKey="Xing, Weiman" sort="Xing, Weiman" uniqKey="Xing W" first="Weiman" last="Xing">Weiman Xing</name>
<name sortKey="Xu, Yuanpeng" sort="Xu, Yuanpeng" uniqKey="Xu Y" first="Yuanpeng" last="Xu">Yuanpeng Xu</name>
<name sortKey="Yang, Bo" sort="Yang, Bo" uniqKey="Yang B" first="Bo" last="Yang">Bo Yang</name>
<name sortKey="Ye, Wenwu" sort="Ye, Wenwu" uniqKey="Ye W" first="Wenwu" last="Ye">Wenwu Ye</name>
<name sortKey="Yu, Feng" sort="Yu, Feng" uniqKey="Yu F" first="Feng" last="Yu">Feng Yu</name>
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	Serveur d'exploration sur les effecteurs du phytophthora
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Serveur d'exploration sur les effecteurs du phytophthora

Phytophthora sojae Effector PsAvh240 Inhibits Host Aspartic Protease Secretion to Promote Infection.

Phytophthora sojae Effector PsAvh240 Inhibits Host Aspartic Protease Secretion to Promote Infection.

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